%20Effectiveness,%20Safety%20&%20Who%20Needs%20It.png)
Manufacture of syrup using steam jacketed kettle
 |
| Manufacture of simple syrup using steam jacketed kettle....pharmacyteach.com |
Introduction
Syrups are sweet, viscous, concentrated aqueous solutions of sucrose or sucrose or other sugar with or without added medical or flavoring agents. When only sucrose is employed in making a syrup then such preparation is called “ simple syrup” or “simplex”.
The manufacture of syrup using a steam-jacketed kettle
involves a process of heating and reducing a liquid mixture of sugar and water
to a syrup consistency. The steam-jacketed kettle is a large vessel with an
outer jacket that is filled with steam to heat the inner contents of the
kettle.
Uses of syrup:
This medication is commonly used to deliver a prescribed dose of medicine to patients who have difficulty swallowing pills or tablets. Syrups are often used to treat various medical conditions, such as coughs, colds, allergies, and digestive disorders. They can also be used to provide nutrition to patients who cannot eat solid food due to illness or surgery. Syrups can be flavored to make them more palatable for patients, especially children.
Also, Read this;
Requirements
Sugar, water, ruler, weighing balance, pycnometer, pH
paper, and steam jacketed kettle.
The concentration of sucrose in simple syrup is expressed as :
66.7% W/W (B.P)
85% W/V (U.S.P)
Procedure Manufacture of syrup using steam jacketed kettle
1 ). Calculation of capacity of the steam jacketed kettle :
First of all, determine the height and diameter of the kettle and
then determine its capacity by following the formula:
V = ( πr^2) h
Subtract a value of 1-5 liters from the determined value as
the actual capacity to allow for the proper mixing because if the kettle is according
to the exact determined value, there are chances of overloading.
2 ). Calculation of the amount of sugar and water required in making the syrup:
For making the syrup of the desired capacity, the amount of
sugar and water required is calculated on the basis of the specific gravity of
simple syrup, following are the values of specific gravity
B. P
(1.315 – 1.333 )
USP not
less than 1.30
How to counsel patients about Medications?
3 ). Preparation of simple syrup ( 85% W/V, USP )
- Combine the sugar and water in the kettle, stirring to dissolve the sugar.
- Turn on the steam supply to the jacket and bring the mixture to a boil, occasionally stirring to prevent scorching.
- Once the mixture reaches boiling, reduce the heat to a simmer and continue stirring. This will help to ensure that the sugar does not crystallize.
- Skim off any foam that forms on the surface of the mixture. This foam is usually composed of impurities and can result in an off-taste in the final product.
- Continue simmering the mixture until it reaches the desired consistency. This can take anywhere from 30 minutes to several hours, depending on the quantity of the mixture and the desired thickness of the syrup.
- Once the syrup has reached the desired consistency, turn off the heat and let it cool. At this point, you can add flavorings or other ingredients if desired.
- Once the syrup has cooled, transfer it to storage containers. The syrup can be stored at room temperature for several months.
Evaluation of the syrup :
Check the following parameter of preparation syrup :
- Specific gravity using a pycnometer. it should comply with required of the USP i.e. not less than 1.30
- pH using pH paper strips, it should comply with the official requirement of being neutral i.e. pH 7.
Safety precautions
%20%20for%20Pain%20Relief%20How%20It%20Works%20&%20What%20You%20Need%20to%20Know..png)
0 Comments