Manufacturing of Aspirin Tablets...step by Step Manufacturing of Aspirin Tablets...

Theory:

Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID) Direct compression or Dry granulation method is normally used in the preparation of aspirin tablets owing to its unstable nature and ability to undergo hydrolysis if made with wet granulation.

tablets are manufactured in various shape but weight,size and thickness of aspirin tablets are depend on amount of dose.

 

Uses of aspirin

Aspirin has been helpful for over an era for its pain-relieving, anti-inflammatory, and fever-reducing properties, and its status in modern medicine cannot be exaggerated. However, it is necessary to think that aspirin can have side effects, particularly in people with certain medical conditions or who are taking other medications. It is important to consult to a doctor before taking any medication, for safe use of medication.

Formula:

Ingredients         Official Formula                         Working                                                                                     Formula

Asp                            0.300g                                            --

Starch Powder 5%     0.015g                                            --

Tale 2%                      0.006g                                           --

 

Calculate the working formula according to tablet count.

 

Step by Step Manufacturing of Aspirin Tablets

 

Requirements

Mortar and Pestle

Compression Machine

 Sieve No 22, 44

• Weighing balance

 

Chemicals:

aspirin

Starch Powder

Talc

 

Procedure of aspirin tablets step by step :

Calculate the working formula depending on the number of tablets to be manufactured. The details follow;

I . weighing

Granular acetylsalicylic acid weighed approximately greater than the required quantity.

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II. screening :

weighed aspirin  is passed through 22/44 mesh sieves. collet the material retained on 44 as coarse granules. Collection of the material that passes through sieve no. 44 as fines.

Fifteen percent  of the fines required are weighed. Five percent of starch powder and 2% of ale powder are weighed.

 

III-Blending

Course granules, fines, arch powder, and sale powder are blended thoroughly in a mortar with a pole in order uniformly distribute the ingredients. The granules are now ready for compression.

A fraction  of the lubricant is added during process and the rest is added after the tablets are compressed step.

 

IV-Compression

Three pockets of grades, each coining the practical weight of one tablet are prepared. These are used to adjust the pressure of the punches in order to get tablets of sufficient hardness. The remaining granules are compressed to obtain Calculate percentage yield using the formula;

Percentage yield=    Actual Yield / Theoretical Yield  x 100

V-Packing:

Compressed tablets are placed in a wide-mouthed, tightly closed container in a cool, dry place. The container is capped and cited.

The manufacturing of  aspirin tablets are now completed and  supply to health cares, drug stores and use under the doctor prescription. 

Quality control 

Throughout the manufacturing process, quality control tests are done to ensure the safety and efficacy of the end product. before the procedure start, it is important  tested Raw materials for quality and purity, and any impurities or contaminants are removed.

During the synthesis of aspirin, reaction conditions are closely monitored to ensure that the reaction proceeds as expected and that the resulting product is of high purity. After synthesis, the aspirin is further purified to remove any remaining impurities.

Tablets are also tested to ensure that they meet specific quality standards, such as the amount of active ingredient per tablet and the rate of dissolution in the body. Any tablets that not approaches  these standards are discarded.

Characteristics of aspirin tablets:

Colour -----------------white crystalline powder

Odor ------------------- no definite smell 

Melting point --------- 138-140 c

Density of aspirin ----1.40gcm-3

solubility ------------- readly sobule in basic medium 

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